CattleMaster 4+VL5 is for vaccination of healthy cattle, including pregnant cows, as an aid in preventing infectious bovine rhinotracheitis caused by infectious bovine rhinotracheitis (IBR) virus, bovine viral diarrhea caused by bovine viral diarrhea (BVD) type 1 virus, disease caused by parainfluenza3 (PI3) virus and bovine respiratory syncytial virus (BRSV), campylobacteriosis (vibriosis) caused by campylobacter fetus and leptospirosis caused by leptospira canicola, L. grippotyphosa, L. hardjo, L. icterohaemorrhagiae and L. pomona. CattleMaster 4+VL5 is a freeze-dried preparation of chemically altered strains of IBR and PI3 viruses and modified live BRSV plus a liquid, adjuvanted preparation of inactivated cytopathic and non-cytopathic BVD type 1 virus strains, C. fetus and cultures of the five leptospira serovars identified above. The liquid component is used to rehydrate the freeze-dried component. Viral antigens are propagated on an established cell line. This product is adjuvanted with aluminum hydroxide to enhance immune response.